Glucagon-like peptide-1 (GLP-1) receptor agonists are incretin analogues that promote glucose-mediated insulin release and are used to treat type 2 diabetes mellitus and obesity. GLP-1 receptor ago...
GLP-1 receptor agonists have reshaped how clinicians and researchers think about metabolic disease, revealing a hormone system that links appetite, reward, emotion, inflammation and cardiovascular health. What began as a strategy for controlling blood sugar has evolved into a window into deeply integrated physiological networks.
Coskun, T. et al. LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: from discovery to clinical proof of concept.
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GLP-1 Receptor Agonists GLP-1 RAs are approved for the treatment of both T2DM and obesity, and emerging evidence suggests they may also play a promising role in the management of metabolic associated steatotic liver disease (MASLD), now recognized as the most prevalent chronic liver disease worldwide [11, 12]. The first GLP-1 RA approved for obesity or overweight with comorbidities was ...
Current developments include the exploration of novel indications (eg, neurodegenerative diseases and substance use disorders) with suggestive evidence of efficacy, and the development of small-molecule GLP-1 receptor agonists for oral treatment to improve convenience.
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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) represent a major advancement in obesity treatment, offering robust efficacy in weight loss and metabolic regulation.
treatment of binge eating disorder with the GLP-1. agonistsemaglutide:Aretrospective cohort study.Purpose Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly used for managing metabolic disorders such as type 2 diabetes mellitus (T2DM) and obesity.
In the brain GLP1 receptor agonists lead to a better glycemic control and they appear to have anti-inflammatory and neuroprotective effects. It has been reported that GLP1 receptor agonists reduce oxidative stress and apoptosis, lower the risk of ischemia and promote neurogenesis.
